Images in Haematology
Acute promyelocytic leukaemia presenting with a myeloid sarcoma of the tongue
S. Mohamedbhai, M. Pule, B. Conn, C. Hopper, A. Ramsay, A. Khwaja
p. 565

Bortezomib-induced reversible posterior leucoencephalopathy syndrome
Kevin Kelly, Roshni Kalachand, Philip Murphy
p. 566
Reviews
Recent advances in the pathogenesis and management of juvenile myelomonocytic leukaemia
Kenichi Koike, Kazuyuki Matsuda
p. 567-575

Farnesyltransferase inhibitors and their potential role in therapy for myelodysplastic syndromes and acute myeloid leukaemia
Thorsten Braun, Pierre Fenaux
p. 576-586

Risk stratification and venous thromboprophylaxis in hospitalized medical and cancer patients
Paolo Prandoni, Michel M. Samama
p. 587-597

Haematological Malignancy
p38 mitogen-activated protein kinase inhibitor LY2228820 enhances bortezomib-induced cytotoxicity and inhibits osteoclastogenesis in multiple myeloma; therapeutic implications
Kenji Ishitsuka, Teru Hideshima, Paola Neri, Sonia Vallet, Norihiko Shiraishi, Yutaka Okawa, Zhenxin Shen, Noopur Raje, Tanyel Kiziltepe, Enrique M. Ocio, Dharminder Chauhan, Pierfrancesco Tassone, Nikhil Munshi, Robert M. Campbell, Alfonso De Dios, Chuan Shih, James J. Starling, Kazuo Tamura, Kenneth C. Anderson
p. 598-606

Prognostic importance of T and NK-cells in a consecutive series of newly diagnosed patients with chronic lymphocytic leukaemia
Shanique Palmer, Curtis A. Hanson, Clive S. Zent, Luis F. Porrata, Betsy LaPlant, Susan M. Geyer, Svetomir N. Markovic, Timothy G. Call, Deborah A. Bowen, Diane F. Jelinek, Neil E. Kay, Tait D. Shanafelt
p. 607-614

The prognostic significance of cytopenia in chronic lymphocytic leukaemia/small lymphocytic lymphoma
Clive S. Zent, Wei Ding, Susan M. Schwager, Megan S. Reinalda, James D. Hoyer, Diane F. Jelinek, Renee C. Tschumper, Deborah A. Bowen, Timothy G. Call, Tait D. Shanafelt, Neil E. Kay, Susan L. Slager
p. 615-621

High density genome-wide DNA profiling reveals a remarkably stable profile in hairy cell leukaemia
Francesco Forconi, Giulia Poretti, Ivo Kwee, Elisa Sozzi, Davide Rossi, Paola M. V. Rancoita, Daniela Capello, Andrea Rinaldi, Emanuele Zucca, Donatella Raspadori, Valeria Spina, Francesco Lauria, Gianluca Gaidano, Francesco Bertoni
p. 622-630
Rapid and sustained clearance of circulating lymphoma cells after chemotherapy plus rituximab: clinical significance of quantitative t(14;18) PCR monitoring in advanced stage follicular lymphoma patients
Carsten Hirt, Frank Schüler, Thomas Kiefer, Cornelia Schwenke, Antje Haas, Dietger Niederwieser, Sabine Neser, Michael Aßmann, Stefanie Srock, Robert Rohrberg, Klaus Dachselt, Malte Leithäuser, Charles S. Rabkin, Michael Herold, Gottfried Dölken
p. 631-640

THOC5 spliceosome protein: a target for leukaemogenic tyrosine kinases that affects inositol lipid turnover
Andrew Pierce, Louise Carney, Hajja G. Hamza, John R. Griffiths, Liqun Zhang, Beth A. Whetton, M. Belen Gonzalez Sanchez, Teruko Tamura, David Sternberg, Anthony D. Whetton
p. 641-650

Relationship between ADAMTS13 activity in clinical remission and the risk of TTP relapse
Ming Jin, T. Charles Casper, Spero R. Cataland, Melanie S. Kennedy, Shili Lin, Yu J. Li, Haifeng M. Wu
p. 651-658
Fatty acid synthase is a novel therapeutic target in multiple myeloma
Yutaka Okawa, Teru Hideshima, Hiroshi Ikeda, Noopur Raje, Sonia Vallet, Tanyel Kiziltepe, Hiroshi Yasui, Sotaro Enatsu, Samantha Pozzi, Iris Breitkreutz, Diana Cirstea, Loredana Santo, Paul Richardson, Kenneth C. Anderson
p. 659-671

Detection of elevated levels of tumour-associated microRNAs in serum of patients with diffuse large B-cell lymphoma
Charles H. Lawrie, Shira Gal, Heather M. Dunlop, Beena Pushkaran, Amanda P. Liggins, Karen Pulford, Alison H. Banham, Francesco Pezzella, Jacqueline Boultwood, James S. Wainscoat, Christian S. R. Hatton, Adrian L. Harris
p. 672-675
Hypoxia inducible factor-alpha activation in lymphoma and relationship to the thioredoxin family
Andrew M. Evens, Paul T. Schumacker, Irene B. Helenowski, Amareshwar T. K. Singh, Danijela Dokic, Anjeni Keswani, Elizabeth Kordeluk, Adekunle Raji, Jane N. Winter, Borko D. Jovanovic, Arne Holmgren, Beverly P. Nelson, Leo I. Gordon
p. 676-680

Paediatric
Functional analysis of JAK3 mutations in transient myeloproliferative disorder and acute megakaryoblastic leukaemia accompanying Down syndrome
Tomohiko Sato, Tsutomu Toki, Rika Kanezaki, Gang Xu, Kiminori Terui, Hirokazu Kanegane, Masayoshi Miura, Souichi Adachi, Masahiro Migita, Shingo Morinaga, Takahide Nakano, Mikiya Endo, Seiji Kojima, Hitoshi Kiyoi, Hiroyuki Mano, Etsuro Ito
p. 681-688

Feasibility of prophylaxis and immune tolerance induction regimens in haemophilic children using fully implantable central venous catheters
Maria Elisa Mancuso, Pier Mannuccio Mannucci, Angelo Sartori, Andrea Agliardi, Elena Santagostino
p. 689-695

Sporadic bloody diarrhoea-associated thrombotic thrombocytopenic purpura-haemolytic uraemic syndrome: an adult and paediatric comparison
Charity A. Karpac, Xiaoning Li, Deirdra R. Terrell, Johanna A. Kremer Hovinga, Bernhard Lämmle, Sara K. Vesely, James N. George
p. 696-707
Platelets, Haemostasis and Thrombosis
Reactivity profile of anti-factor VIII antibodies with designed synthetic peptides mimicking epitopes of the C2 and a1 domains
D. G. Chaves, C. Velloso-Rodrigues, V. Moreau, C. Nguyen, S. Villard, A. R. Belisário, C. Granier, M. M. Santoro
p. 708-715
Fibrinolytic inhibitor levels and polymorphisms in Behçet disease and their association with thrombosis
José M. Ricart, Luis A. Ramón, Amparo Vayá, Francisco España, Maria-Luisa Santaolaria, José Todolí, Remedios Castelló, Jordi Fontcuberta, Amparo Estellés
p. 716-719
Red Cells and Iron
Induction of gamma-globin gene transcription by hydroxycarbamide in primary erythroid cell cultures from Lepore patients
Roberta Calzolari, Alice Pecoraro, Vito Borruso, Antonio Troia, Santina Acuto, Aurelio Maggio, Rosalba Di Marzo
p. 720-727
Effect of deferasirox (ICL670) on arterial function in patients with beta-thalassaemia major
Y. F. Cheung, Godfrey C. F. Chan, S. Y. Ha
p. 728-733
Correspondence
Early stage chronic lymphocytic leukaemia carrying unmutated IGHV genes is at risk of recurrent infections during watch and wait
Davide Rossi, Lorenzo De Paoli, Francesca M. Rossi, Michaela Cerri, Clara Deambrogi, Silvia Rasi, Antonella Zucchetto, Daniela Capello, Valter Gattei, Gianluca Gaidano
p. 734-736
Marrow osteopontin level as a prognostic factor in acute myeloid leukaemia
Cheng-Yeh Lee, Hwei-Fang Tien, Hsin-An Hou, Wen-Chien Chou, Liang-In Lin
p. 736-739
csf1 is required for early embryonic macrophage development: characterization of the csf1op/csf1op mutation in ES cell-derived macrophages
Robyn M. B. Loureiro, Kelli-Ann Monaco, Joseph B. Kearney, Courtney E. Blickarz-Durand, Suzanne L. Kirby, Maneesha S. Inamdar, Victoria L. Bautch
p. 739-742
Chronic lymphocytic leukaemia and acute myeloid leukaemia are not associated with AKT1 pleckstrin homology domain (E17K) mutations
T. Zenz, K. Döhner, T. Denzel, H. Döhner, S. Stilgenbauer, L. Bullinger
p. 742-743
Gemtuzumab ozogamicin plus cytarabine in elderly patients with relapsed or refractory acute myeloid leukaemia
Jérôme Doyen, Antoine Italiano, Frédéric Peyrade, Claude Bouyer, Antoine Thyss
p. 744-745
Pleural effusions in patients with chronic myeloid leukaemia treated with dasatinib may have an immune-mediated pathogenesis
Hugues de Lavallade, Sinthiya Punnialingam, Dragana Milojkovic, Marco Bua, Jamshid S. Khorashad, Ian H. Gabriel, Aristeidis Chaidos, Eduardo Olavarria, John M. Goldman, Jane F. Apperley, David Marin
p. 745-747 |